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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Main Interactions:See also: interactions.
  • Nitrates: Itraconazole is a nitrate that may cause a drop in blood pressure when used with Cialis. If combined with Cialis, this may cause a sudden and severe drop in blood pressure that can lead to dizziness, fainting, or stroke, leading to symptoms like headache, dizziness, lightheadedness, or fainting.
  • Alpha-blockers: Although not a direct interaction, using Nootropic, such as doxazosin or tamsulosin, could worsen side effects like dizziness or fainting, which require close monitoring by your doctor.
  • Other Antihypertensive Drugs: For cases of combined, severe blood pressure problems, use Cialis with at least one type of medication of your choice.
  • If you take Cialis with other medications of your choice, such as prescription drugs (e.g.

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    Description

    Indication

    Onset of action:Treating erectile dysfunction with Cialis or Viagra

    Contraindications/autopsy

    Route of administration:Intraurethral

    Interactions:CYP2D6 is a reduced enzyme responsible for clearance of testosterone from the body. Low-dose citalopopram, a CYP2D6 substrate, decreases plasma concentrations of tadalafil. Combining these drugs increases the potential for an increase in tadalafil exposure. Hepatic impairment, aplastic anemia, or major surgery are contraindicated. Erectile dysfunction should be corrected with systemic absorption and not�cialis is contraindicated in patients with a previous history of heart attack, stroke, or life-threatening arrhythmias. Hepatic dysfunction has been shown to be associated with an increased risk of cardiac events, including heart failure. Renal impairment has been shown to be associated with an increased risk of developing pulmonary hypertension (PAH).

    Dosage (milligrams) / day

    Therapeutic Category:Tadalafil: oral; Cialis: tablet, beaker, oral; sildenafil: tablet; tadalafil citrate: tablet; tadalafil 10mg: tablet; sildenafil 20mg: tablet; sildenafil 50mg: tablet; tadalafil 80mg: tablet; sildenafil 100mg: tablet; sildenafil 120mg: tablet; tadalafil 200mg: tablet; tadalafil 400mg: tablet; tadalafil 800mg: tablet; sildenafil 100mg / 200mg: tablet; sildenafil 500mg / 800mg: tablet; sildenafil 800mg / 400mg: tablet; sildenafil 1000mg / 850mg: tablet; sildenafil 1000mg 100pk: tablet; sildenafil 100mg / 200mg: tablet; sildenafil 50mg / 50mg: tablet; sildenafil 50mg 100pk: tablet; tadalafil 50mg 100pk: tablet; tadalafil 100mg / 200mg 100pk: tablet; tadalafil 50mg 100pk: tablet; sildenafil 100mg 100pk: tablet; tadalafil 100mg 100pk: tablet; sildenafil 50mg 100pk: tablet; sildenafil 100mg 100pk: tablet; sildenafil 100mg 100pk: tablet; sildenafil 100mg 100pk: tablet; sildenafil 100mg 100pk: tablet; sildenafil 100mg 100pk: tablet; sildenafil 100mg 100pk: tablet; sildenafil 100mg 100pk: tablet; sildenafil 100mg 100pk: tablet; sildenafil 100mg 100pk: tablet. Cialis: tablet, beaker, oral.

    Cialis (Tadalafil) / Tadalafil (Cialis) Dosage

    Cialis and Cialis (Tadalafil) tablets are prescription medications for:

    • Men who have erectile dysfunction (ED) or have impotence; or
    • Those with heart problems or heart failure.

    Cialis and Cialis (Tadalafil) tablets must be taken at the same time to get the best benefit. You must follow your doctor’s instructions on how to take the medication. Cialis (Tadalafil) tablets have a short half-life of about 4.5 hours.

    The recommended dose of Cialis and Cialis (Tadalafil) tablets for ED and impotence is 50 mg taken as needed, about an hour before sexual activity.

    The recommended dose for Cialis and Cialis (Tadalafil) tablets for PAH is 100 mg taken as needed, about an hour before sexual activity.

    The dosage of a Cialis and Cialis (Tadalafil) tablet for PAH is also determined by your doctor. The first dose should be taken at the same time every day.

    What is Viagra?

    The active ingredient of theViagraprescription isSildenafil. Thisgeneric Viagrais a PDE5 inhibitor. It is used to treat erectile dysfunction. It works by helping to relax the blood vessels in the penis, allowing blood to flow into the penis when the penis is erect. This increased blood flow helps to achieve and maintain an erection.

    Sildenafil relaxes the blood vessels in the penis, allowing for an erection. This allows the user to achieve and maintain an erection.

    How does Viagra work?

    Sildenafil is a PDE5 inhibitor. It blocks the enzyme PDE5 in the body. It helps to relax the blood vessels in the penis, allowing for an erection.

    The medication works by inhibiting the action of an enzyme called PDE5. This enzyme can be found in the penis, but it does not cause an erection. The erection is only possible when the user is sexually stimulated. In other words, the user is not producing an erection. When the user is sexually stimulated, they become sexually aroused. This is why it is essential to use Viagra properly to avoid any side effects.

    What are the side effects of Viagra?

    The most common side effects of Viagra are:

    • Nausea
    • Headache
    • Flushing
    • Nasal congestion
    • Back pain
    • Sensitivity to light
    • Swelling in the face, chest, or abdomen

    These side effects are usually mild to moderate and go away after a few hours. If you experience more severe side effects, such as chest pain, severe allergic reactions, or sudden vision loss, consult your doctor immediately.

    How do I take Viagra?

    Take Viagra exactly as prescribed by your doctor. You can take Viagra with or without food, but taking it with a high-fat meal can delay the onset of the effects. You can take Viagra with or without food, but you can take it with or without water. If you miss a dose, take it as soon as you remember, but take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at one time.

    Avoid taking more than prescribed. Taking more than the prescribed amount can increase your chance of experiencing side effects. If you experience any serious side effects such as chest pain, chest pain, or sudden vision loss, seek immediate medical attention.

    Can I take Viagra on an empty stomach?

    It is recommended to take Viagra on an empty stomach, as the medication can delay the action of the PDE5 enzyme. However, it is not recommended to take it with dairy products or other similar antacids. It is also important to take Viagra with a high-fat meal. If you experience any serious side effects, contact your doctor immediately.